Phenotyping rare hepcidin deficiency
نویسندگان
چکیده
منابع مشابه
Hepcidin and the global burden of iron deficiency.
Iron deficiency anemia is the most common type of anemia worldwide. It primarily affects women and children and is particularly prevalent in regions where their diet contains little meat, malaria and intestinal parasites are common, women have many closely spaced pregnancies, and children suffer from diarrheal illnesses (1 ). Iron deficiency alone or in combination with other forms of malnutrit...
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We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout mice. In these mice, as in murine models of hemochromatosis and patients with hereditary hemochromatosis, iron accumulates in parenchymal cells (in particular, liver and pancreas), whereas the reticuloendothelial system is spared from this iron loading. We suggested that this phenotypic trait could be attribut...
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Tuberculosis (TB), caused by the macrophage-tropic pathogen Mycobacterium tuberculosis (M.tb) is a highly prevalent infectious disease. Since an immune correlate of protection or effective vaccine have yet to be found, continued research into host-pathogen interactions is important. Previous literature reports links between host iron status and disease outcome for many infections, including TB....
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-05-851634